Search results for "Hippocampal atrophy"
showing 4 items of 4 documents
IC‐P‐024: Localization of hippocampal atrophy in Alzheimer's disease
2011
The hippocampus presents the highest rate of atrophy in the early stage of Alzheimer's disease (AD), with more pronounced neuron loss reported in CA1 and subiculum. The aim of this study is to increase the discrimination power of hippocampal shape analysis between AD and normal controls (NC) by focusing on the subregions with atrophy associated with AD and describing the localized shape changes using statistical shape models (SSMs).
Functional implications of hippocampal volume and diffusivity in mild cognitive impairment.
2005
Abstract Hippocampal atrophy has been related to mild cognitive impairment (MCI) and early Alzheimer disease (AD), but the diagnostic significance of cross-sectionally determined hippocampal volumes is still ambiguous. Diffusion-Tensor-Imaging (DTI) in MCI patients revealed an association of microstructural changes in hippocampal areas with verbal memory decline. MRI volumetry and DTI were combined to investigate 18 MCI patients attending a memory clinic, and 18 carefully age- and gender-matched healthy controls. Neuropsychological testing, high resolution T1-weighted volume MRI scans, and DTI scans with regions-of-interest in hippocampal areas were applied. Left hippocampal volume was sign…
Differential associations of age with volume and microstructure of hippocampal subfields in healthy older adults
2015
Hippocampal atrophy in advanced healthy aging has frequently been reported. However, the vulnerability of different hippocampal subfields to age-related atrophy is still a source of debate. Moreover, the association of age with the microstructural integrity of subfields is largely unknown. In this study, we investigated the associations between age and volume as well as microstructural integrity of hippocampal subfields using a three-dimensional (3D) surface mapping approach. Forty-three healthy older adults spanning the age range from 60 to 85 years underwent T1-weighted and diffusion-tensor imaging. Analyses demonstrated an association of age with hippocampal volume predominantly in the m…
Increasing power to predict mild cognitive impairment conversion to Alzheimer's disease using hippocampal atrophy rate and statistical shape models
2010
Identifying mild cognitive impairment (MCI) subjects who will convert to clinical Alzheimer's disease (AD) is important for therapeutic decisions, patient counselling and clinical trials. Hippocampal volume and rate of atrophy predict clinical decline at the MCI stage and progression to AD. In this paper, we create p-maps from the differences in the shape of the hippocampus between 60 normal controls and 60 AD subjects using statistical shape models, and generate different regions of interest (ROI) by thresholding the p-maps at different significance levels. We demonstrate increased statistical power to classify 86 MCI converters and 128 MCI stable subjects using the hippocampal atrophy rat…